Climate change poses multifaceted challenges to plant ecosystems, significantly affecting Non-mulberry plants through both abiotic and biotic stressors. This chapter explores the responses of Non-mulberry plants to these stresses, emphasizing the intricate crosstalk between different signalling pathways and the resulting trade-offs in resource allocation. Abiotic stressors such as temperature extremes, water scarcity, soil salinity, and increased UV radiation alter plant physiology and trigger complex defense mechanisms. Concurrently, biotic challenges from pathogens and insect pests exert additional pressures, compelling plants to balance growth and defense strategies. The interaction between abiotic and biotic stress responses is mediated by sophisticated signalling networks involving phytohormones, genetic, and epigenetic regulations. These interactions often result in trade-offs, particularly between growth and defense, and influence reproductive success and long-term evolutionary adaptation. Through detailed case studies and comparative analyses, this chapter sheds light on the diverse responses of Non-mulberry plants, providing insights into their adaptive strategies. The chapter concludes with an exploration of future research directions, technological advancements, and implications for agriculture and conservation, offering policy and management recommendations to mitigate the impacts of climate change on plant ecosystems.