The interactions of humanity and nature have given rise to complex problems, which operate across a range of scales from global to local and cascade through environmental, economic, socio-cultural, and political systems. Modern science and disciplinary investigation have often been conducted using a reductionist approach, which isolates phenomena into simpler single components to investigate them in detail. This approach has proven effective, but the complexity of sustainability issues means that they are likely to defy simple characterisations or solutions provided by single disciplines. Instead, there have been calls for research to take a more holistic approach. This gives rise to challenges and also opportunities, for example, with the foundation of new fields of study such as ‘sustainability science’ and ‘sustainability studies’. In this chapter we introduce some of the core approaches for research collaboration across the disciplines: multidisciplinarity, interdisciplinarity, and transdisciplinarity. We review the challenges of working across different disciplines and explore how these could be overcome. We consider the competences which can help foster collaboration and report how these have been deployed from small- to large-scale research and participatory projects. These projects have engaged with problems such as climate change, biodiversity loss, sea-level rise, heritage loss and societal challenges including migration. How can a range of insights be brought together from diverse perspectives in an inclusive way, without causing cognitive overload, or falling into an impasse of relativism? Interdisciplinary approaches are perhaps most challenging where they involve collaboration across fields where there are radically different assumptions and ways of working. Here the authors draw upon their backgrounds in natural sciences, humanities, and social sciences to consider ways to bridge these major differences and combine the insights from different fields of knowledge. The final sections offer practical tips for working in collaborative teams on sustainability issues which can support readers in their practice and implementation of interdisciplinary approaches. These are core skills we will need to craft more sustainable futures.