Anode effect (AEAnode Effect (AE)) is a common failure in the aluminum productionAluminum production process due to the numerous negative influences in electrolysis cellsElectrolysis cell. In this paper, the response of zone anode currentZone anode current to AEAnode Effect (AE) was analyzed systematically. The results showed that the zone anode currentsZone anode current in all zones fluctuated dramatically during the occurrence of the global AEAnode Effect (AE). However, in tens of seconds before this, there would always be a zone where the zone anode currentZone anode current first dropped (called the initial response zone, IRZ), with a probability of 59.3%, this happening in the end zones of the cell, much higher than the middle zones. Meanwhile, the probability of the second zone where the zone anode currentZone anode current decreased (called the secondary response zone, SRZ) being adjacent to the IRZ was over 90%. The characteristics of zone anode currentZone anode current changes in the IRZ provide conditions for early warning and intervention of AEAnode Effect (AE).