3D-Printed PLGA Scaffolds: Current Progress and Prospects for Soft-Tissue Engineering
摘要
Poly(lactic-co-glycolic acid) (PLGA) is a widely used FDA-approved bioresorbable copolymer whose tunable degradation, mechanical propertiesMechanical properties and processability make it attractive for tissue engineering. Additive manufacturingAdditive manufacturing (3D printing3D printing) has enabled fabrication of patient-specific, porous PLGA scaffolds with controlled architecture. This mini-review summarizes recent advances in fabrication methods for 3D-printed PLGA scaffolds, strategies for compositing and biofunctionalization, and demonstrated applications in soft-tissue engineering (dermal/wound, adipose, muscle/tendon, and nerve). Key technical challenges (printing-induced polymerPolymer degradation, matching mechanical compliance for soft tissues, vascularization, controlled bioactive release, and regulatory translation) are discussed and near-term prospects outlined. Representative recent experimental works are reviewed to highlight successes and limitations.