Poly(lactic-co-glycolic acid) (PLGA) is a widely used FDA-approved bioresorbable copolymer whose tunable degradation, mechanical propertiesMechanical properties and processability make it attractive for tissue engineering. Additive manufacturingAdditive manufacturing (3D printing3D printing) has enabled fabrication of patient-specific, porous PLGA scaffolds with controlled architecture. This mini-review summarizes recent advances in fabrication methods for 3D-printed PLGA scaffolds, strategies for compositing and biofunctionalization, and demonstrated applications in soft-tissue engineering (dermal/wound, adipose, muscle/tendon, and nerve). Key technical challenges (printing-induced polymerPolymer degradation, matching mechanical compliance for soft tissues, vascularization, controlled bioactive release, and regulatory translation) are discussed and near-term prospects outlined. Representative recent experimental works are reviewed to highlight successes and limitations.

错误:搜索内容不能为空,请输入英文关键词
错误:关键词超出字数限制,请精简
高级检索

3D-Printed PLGA Scaffolds: Current Progress and Prospects for Soft-Tissue Engineering

  • Gregory E. Onaiwu,
  • Bem Isaac Angwe,
  • Aireguamen I. Aigbodion,
  • Ngozi M. Uzoekwe,
  • Eseosa Uwadiae,
  • Mathias Eromosele Okojie,
  • Samuel Ugheighele,
  • Sunday Oghenetega,
  • Khazuagbe H. Ifijen

摘要

Poly(lactic-co-glycolic acid) (PLGA) is a widely used FDA-approved bioresorbable copolymer whose tunable degradation, mechanical propertiesMechanical properties and processability make it attractive for tissue engineering. Additive manufacturingAdditive manufacturing (3D printing3D printing) has enabled fabrication of patient-specific, porous PLGA scaffolds with controlled architecture. This mini-review summarizes recent advances in fabrication methods for 3D-printed PLGA scaffolds, strategies for compositing and biofunctionalization, and demonstrated applications in soft-tissue engineering (dermal/wound, adipose, muscle/tendon, and nerve). Key technical challenges (printing-induced polymerPolymer degradation, matching mechanical compliance for soft tissues, vascularization, controlled bioactive release, and regulatory translation) are discussed and near-term prospects outlined. Representative recent experimental works are reviewed to highlight successes and limitations.