As virtual learning environments continue to expand in science, technology, engineering, and mathematics (STEM) education, concerns about student safety have become increasingly significant. While traditional science classrooms implement rigorous safety protocols to prevent accidents and ensure ethical practices, STEM virtual learning environments (VLEs) present unique challenges, such as data privacy risks and the potential to misuse digital tools and simulations. Through comparative document content analysis, this chapter examines key safety concerns in STEM VLEs, focusing on data protection, ethical considerations in virtual experimentation, and strategies for promoting responsible digital citizenship. Additionally, it explores best practices educators can implement to mitigate these risks, such as secure learning platforms, strong authentication measures, clear guidelines for online collaboration, and the integration of digital literacy skills into STEM curricula. Effective strategies for maintaining student safety while fostering innovation and engagement in STEM VLEs were also identified. By synthesizing diverse policies and practices, the chapter adds to existing literature by framing digital safety as both a pedagogical and ethical imperative. The findings suggest that a safe and secure digital learning environment depends on proactive policies, comprehensive teacher training, and increased student awareness, highlighting the need to balance technological advancements with safety considerations in STEM VLEs.