Immersive Virtual Reality (VR) offers unique virtual learning experiences by leveraging 3D visualisation and full-body interactions. The purpose of this chapter is to synthesise the existing literature and critically evaluate the benefits, challenges, and future directions of adopting immersive VR in science practicals. Educators generally adopt VR to extend real-world fieldwork to hard-to-reach areas, support unconstrained experimentation, and provide accessible, safe, cost-effective, and ethically sound alternatives to in-person experiments. Studies indicate that VR is particularly effective when the experiences support iterative experimentation, yet its learning benefits vary depending on students’ prior knowledge and experience with VR. VR remains less effective in developing hands-on laboratory skills due to limited tactile feedback. Many VR applications follow prescriptive, step-by-step designs that constrain inquiry-based, collaborative learning, limiting one of VR’s key benefits: risk-free, problem-solving exploration. To maximise the educational potential of VR, educators should further explore how to address the existing design challenges to offer pedagogically sound learning experiences with the technology.