The integration of digital technologies in science education has transformed traditional approaches to practical work, enabling more accessible, scalable, and engaging learning experiences. This chapter explores the evolving role of virtual laboratories, particularly 3D animated simulations, in supporting practical work in Biology education. It begins by discussing the pedagogical rationale for virtual labs in the digital era, highlighting benefits such as enhanced conceptual understanding, increased student motivation, and improved accessibility for resource-constrained settings. The chapter then delves into the design principles and educational affordances of 3D animated simulations, using a Malaysian curriculum-aligned virtual lab as a case study. This virtual lab, focused on core Biology topics such as nutrition and the human digestive system, exemplifies how animation and interactivity can bridge the gap between theoretical knowledge and hands-on experience. Broader implications are discussed, including challenges in implementation, teacher readiness, and the future role of digital tools in fostering inquiry-based, student-centered learning in science education worldwide.