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FluorohydroxyapatiteFluorohydroxyapatite (FHA, Ca10(PO4)6(OH)2-2xF2x) offers a tunable balance between the bioactivity of hydroxyapatite and the thermal/chemical stability of fluorapatite. However, synthesizing nanoscale FHA with high crystallinity and precise fluorine substitutionFluorine substitution while minimizing CaF2 and secondary phases remains challenging. In this work, FHA nanopowders with varied theoretical fluorine substitutionFluorine substitution (0–100%) were synthesized via two scalable aqueous routes: a modified precipitation method and a urea-assisted hydrothermalUrea-assisted hydrothermal process. The phase compositions, lattice parameters, crystallinities, particle morphologies/size distributions, dispersibilities, and actual fluorine incorporations of the samples were evaluated. The precipitation route produced phase-pure nano-FHA with sharp diffraction peaks, predictable lattice contraction with increasing fluorine content, sphere/rod-like morphologies, and negligible residual CaF2 after calcination, indicating high substitution efficiency and thermal stability. The product also exhibited a relatively weak microwaveMicrowave response, which will be beneficial for suppressing its decomposition during microwaveMicrowave synthesis of titanium-based biocomposites. The hydrothermal route yielded larger rods and exhibited secondary calcium-phosphate phases after high-temperatureTemperature exposure. These results establish processing–structure–property relationships that enable reliable synthesis of high-quality nano-FHA across a wide substitution range, providing powders suitable for biomedical applications.

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Aqueous Synthesis of Nano-Fluorohydroxyapatite with Controlled Fluorine Substitution for Biomedical Applications

  • 会议论文

  • 发表日期：

    2026年

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  • Shangyong Zuo,
  • Xiupeng Zhu,
  • Qian Peng,
  • Morsi M. Mahmoud,
  • Zhiwei Peng

摘要

FluorohydroxyapatiteFluorohydroxyapatite (FHA, Ca10(PO4)6(OH)2-2xF2x) offers a tunable balance between the bioactivity of hydroxyapatite and the thermal/chemical stability of fluorapatite. However, synthesizing nanoscale FHA with high crystallinity and precise fluorine substitutionFluorine substitution while minimizing CaF2 and secondary phases remains challenging. In this work, FHA nanopowders with varied theoretical fluorine substitutionFluorine substitution (0–100%) were synthesized via two scalable aqueous routes: a modified precipitation method and a urea-assisted hydrothermalUrea-assisted hydrothermal process. The phase compositions, lattice parameters, crystallinities, particle morphologies/size distributions, dispersibilities, and actual fluorine incorporations of the samples were evaluated. The precipitation route produced phase-pure nano-FHA with sharp diffraction peaks, predictable lattice contraction with increasing fluorine content, sphere/rod-like morphologies, and negligible residual CaF2 after calcination, indicating high substitution efficiency and thermal stability. The product also exhibited a relatively weak microwaveMicrowave response, which will be beneficial for suppressing its decomposition during microwaveMicrowave synthesis of titanium-based biocomposites. The hydrothermal route yielded larger rods and exhibited secondary calcium-phosphate phases after high-temperatureTemperature exposure. These results establish processing–structure–property relationships that enable reliable synthesis of high-quality nano-FHA across a wide substitution range, providing powders suitable for biomedical applications.