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The formulation of polymeric emulsions for the encapsulation and controlled release of bioactive compounds offers significant potential for adjunctive cancer therapies, particularly in leukemia, by mitigating oxidative stress. In this work, we report the preparation and characterization of emulsions based on poly(ε-caprolactone) (PCL) and polyvinyl alcohol (PVA), incorporating a tocols-rich extract (TRE). The effects of PVA concentration (2% and 4% w/v) and ultrasonic agitation time (1, 5, and 15 min) on emulsion stability were studied. In addition, two chloroform removal strategies were compared: water bath evaporation and convection oven drying, both at 60 ℃. Incomplete evaporation was observed in both cases, as suggested by residual odor and crust formation, which negatively impacted emulsion stability. Colloidal stability was evaluated by turbidimetry at 600 nm over 24 h at 25 ℃ in kinetic mode. Aggregation and phase separation were visually confirmed. A Folin–Ciocalteu-based colorimetric assay was adapted to quantify TRE and determine encapsulation efficiency, using a calibration curve from methanolic TRE standards. While emulsions were initially formed, post-evaporation destabilization suggests that optimization of solvent removal and formulation parameters is necessary.

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Stabilization of Tocols-Rich Extract in Polymeric Emulsions Toward a Controlled Delivery System for Leukemia Adjuvant Therapy

  • 会议论文

  • 发表日期：

    2026年

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  • Nancy Mineth Pérez López,
  • Valeria Pérez Monarrez,
  • Paola Valeria Galván González,
  • Laura Alejandra de la Rosa,
  • Christian Chapa González

摘要

The formulation of polymeric emulsions for the encapsulation and controlled release of bioactive compounds offers significant potential for adjunctive cancer therapies, particularly in leukemia, by mitigating oxidative stress. In this work, we report the preparation and characterization of emulsions based on poly(ε-caprolactone) (PCL) and polyvinyl alcohol (PVA), incorporating a tocols-rich extract (TRE). The effects of PVA concentration (2% and 4% w/v) and ultrasonic agitation time (1, 5, and 15 min) on emulsion stability were studied. In addition, two chloroform removal strategies were compared: water bath evaporation and convection oven drying, both at 60 ℃. Incomplete evaporation was observed in both cases, as suggested by residual odor and crust formation, which negatively impacted emulsion stability. Colloidal stability was evaluated by turbidimetry at 600 nm over 24 h at 25 ℃ in kinetic mode. Aggregation and phase separation were visually confirmed. A Folin–Ciocalteu-based colorimetric assay was adapted to quantify TRE and determine encapsulation efficiency, using a calibration curve from methanolic TRE standards. While emulsions were initially formed, post-evaporation destabilization suggests that optimization of solvent removal and formulation parameters is necessary.