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A paper-based microanalytical device (µPAD) was developed for the real-time analysis of freshly collected human saliva, addressing a key challenge in point-of-care diagnostics by eliminating the need for pretreatment. The wax-printed channel design ensures efficient fluid transport, even in the presence of cellular components and formed elements. The physicochemical properties of saliva - including density, viscosity, and pH- were experimentally characterized and computationally modeled to evaluate the device performance. A filling time of 3 min was achieved using 90 µL of sample, demonstrating rapid and clog-free transport. Additionally, a direct correlation between channel geometry and flow behavior was identified, confirmed by MATLAB® simulations, and used to inform design optimization. These findings support the viability of the µPAD as a versatile diagnostic tool.

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New Insights into μPAD Design for Freshly Extracted Human Saliva

  • 会议论文

  • 发表日期：

    2026年

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  • Yahir Hernández Navarrete,
  • Paulina Hernández-Garcés,
  • Nikola Batina Skeledjzija

摘要

A paper-based microanalytical device (µPAD) was developed for the real-time analysis of freshly collected human saliva, addressing a key challenge in point-of-care diagnostics by eliminating the need for pretreatment. The wax-printed channel design ensures efficient fluid transport, even in the presence of cellular components and formed elements. The physicochemical properties of saliva - including density, viscosity, and pH- were experimentally characterized and computationally modeled to evaluate the device performance. A filling time of 3 min was achieved using 90 µL of sample, demonstrating rapid and clog-free transport. Additionally, a direct correlation between channel geometry and flow behavior was identified, confirmed by MATLAB® simulations, and used to inform design optimization. These findings support the viability of the µPAD as a versatile diagnostic tool.