Microfluidic-Mechanical Bioreactor System for Cardiac Tissue
摘要
A hybrid hydraulic–mechanical cardiac bioreactor was designed, incorporating tissue engineering principles aimed at improving, maintaining, or replacing the physiological conditions of cardiac tissues. This system seeks to emulate the physiological environment of the heart by providing mechanical and hydraulic stimulation to cells through the implementation of an inlet and outlet channel, along with a mechanical piston to simulate heartbeats. Tools such as SolidWorks Flow Simulation were used to model and simulate the dynamic behavior of laminar flow and internal pressure within the system, using the physical properties of water, including an isothermal Newtonian liquid. The printing technique used was stereolithography, and the material was a photocurable resin (Anycubic) with an elastic modulus (E) of 1.2 GPa and a Poisson’s ratio of 0.3. Simulation results showed velocities ranging from 0.002 m/s to 0.016 m/s, with an internal pressure drop of 101325 Pa, indicating a homogeneous and continuous flow distribution that avoids stagnation zones.