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NanothermometryNanothermometry enablesMolecular thermostat precise temperature measurement at the nanoscale, providing critical insights into biological, chemical, and physical processes. Gold nanoparticlesGold nanoparticles (AuNPs), with their unique optical properties, serve as excellent platforms for nanoscale temperature sensing. When functionalized with stem-loop DNAStem-loop DNA structures exhibiting various melting points, these systems achieve high sensitivity in detecting temperature changes through conformational switching. This manuscript reviews the principles, fabrication strategies, and characterization of AuNP-DNA nanothermometers, highlighting their potential for applications in biomedical diagnostics, photothermal therapy monitoring, catalysis, and other nanoscale processes. The combination of plasmonicPlasmonics nanoparticles with programmable nucleic acids provides a robust, tunable, and biocompatible system for real-time thermal sensing and temperature mapping. The nanothermometers were characterized using various techniques, including fluorescence spectroscopy, scanning electron microscopy (SEM)Scanning Electron Microscopy (SEM), UV–Vis spectroscopy, and phase analysis light scattering (PALS).

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Molecular Thermostats: Programmable DNA-Nanoparticle Hybrids for Temperature Mapping

  • 会议论文

  • 发表日期：

    2026年

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  • Simona E. Hunyadi Murph,
  • Will Farr

摘要

NanothermometryNanothermometry enablesMolecular thermostat precise temperature measurement at the nanoscale, providing critical insights into biological, chemical, and physical processes. Gold nanoparticlesGold nanoparticles (AuNPs), with their unique optical properties, serve as excellent platforms for nanoscale temperature sensing. When functionalized with stem-loop DNAStem-loop DNA structures exhibiting various melting points, these systems achieve high sensitivity in detecting temperature changes through conformational switching. This manuscript reviews the principles, fabrication strategies, and characterization of AuNP-DNA nanothermometers, highlighting their potential for applications in biomedical diagnostics, photothermal therapy monitoring, catalysis, and other nanoscale processes. The combination of plasmonicPlasmonics nanoparticles with programmable nucleic acids provides a robust, tunable, and biocompatible system for real-time thermal sensing and temperature mapping. The nanothermometers were characterized using various techniques, including fluorescence spectroscopy, scanning electron microscopy (SEM)Scanning Electron Microscopy (SEM), UV–Vis spectroscopy, and phase analysis light scattering (PALS).