Advances in additive manufacturingAdditive manufacturing (AM) enable the creation of complex geometries that replicate the porous architecture of bone, especially for use in tissue engineering scaffolds. Hybrid scaffoldsHybrid scaffolds merge different unit cells, porosity gradients, and patterns to achieve superior properties. This study investigates the effect of horizontal and radial hybridisation strategies on the mechanical and fluid flow capabilities of TPMS-Voronoi hybrid scaffoldsHybrid scaffolds. All the designs had a similar porosity level of nearly 55%. Fused deposition modelling (FDM) and polylactic acid (PLA) were chosen as the manufacturing mode and raw material. Radial hybridization exhibited better strength, Young’s modulus and energy absorption than the horizontal ones. Horizontal designs showed lower strength compared to the uniform Voronoi design. All the hybrid scaffoldsHybrid scaffolds had excellent permeabilityPermeability performance compared to the uniform Voronoi scaffold. Overall, radial design with TPMS sandwiched between Voronoi (R2), performed best in all aspects. These results pave the way for designing new-generation scaffolds that can improve orthopaedic patient outcomes.