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The coronavirus disease 2019 (COVID-19) was a public health emergency that affected millions of people around the world. People with severe psychotic disorders, such as schizophrenia, showed significantly worse COVID-19-related outcomes in comparison to those without a history of psychosis. Here, we focus on patients who had their first episode of psychosis during COVID-19. We hypothesize that the first psychotic episode in these patients was predestined by a premorbid alteration of emotional perception. The study included 20 patients with schizophrenia (11 women, 9 men) and 20 control participants (12 women, 8 men). We conducted an odd-ball paradigm using four types of stimuli (pleasant, unpleasant, and neutral) and analyzed event-related potentials, ERP. For congruent stimuli in both groups, the amplitudes of the P100 and P3b’ components of the ERP elicited by pleasant stimuli were significantly higher than those elicited by unpleasant stimuli (such as coughing sounds). The amplitude of the N200 component elicited by unpleasant congruent stimuli was higher than that elicited by pleasant stimuli. Patients with schizophrenia showed a higher amplitude of the P3b component elicited by pleasant congruent stimuli compared to non-congruent stimuli. This difference correlated with the severity of COVID-19 symptoms. Altogether, these results suggest that first-episode psychosis in patients with schizophrenia during COVID-19 was linked to a shift in emotional perception.

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EEG Features of Multimodal Emotional Perception in Patients with First-Episode Psychosis That Occurred during COVID-19

  • 会议论文

  • 发表日期：

    2026年

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  • Aleksandra Maslennikova,
  • Olga Martynova,
  • Galina Portnova

摘要

The coronavirus disease 2019 (COVID-19) was a public health emergency that affected millions of people around the world. People with severe psychotic disorders, such as schizophrenia, showed significantly worse COVID-19-related outcomes in comparison to those without a history of psychosis. Here, we focus on patients who had their first episode of psychosis during COVID-19. We hypothesize that the first psychotic episode in these patients was predestined by a premorbid alteration of emotional perception. The study included 20 patients with schizophrenia (11 women, 9 men) and 20 control participants (12 women, 8 men). We conducted an odd-ball paradigm using four types of stimuli (pleasant, unpleasant, and neutral) and analyzed event-related potentials, ERP. For congruent stimuli in both groups, the amplitudes of the P100 and P3b’ components of the ERP elicited by pleasant stimuli were significantly higher than those elicited by unpleasant stimuli (such as coughing sounds). The amplitude of the N200 component elicited by unpleasant congruent stimuli was higher than that elicited by pleasant stimuli. Patients with schizophrenia showed a higher amplitude of the P3b component elicited by pleasant congruent stimuli compared to non-congruent stimuli. This difference correlated with the severity of COVID-19 symptoms. Altogether, these results suggest that first-episode psychosis in patients with schizophrenia during COVID-19 was linked to a shift in emotional perception.