In this paper, a fifth-order adaptive network model is presented, which explains the role of epigenetic modification in Borderline Personality Disorder (BPD) and its relation to early life stressors. Research has found that epigenetic processes influenced by childhood adversity can lead to decreased expression of the NR3C1 (GR) gene in patients with BPD. This affects the neuroendocrine stress regulation system and results in increased cortisol levels. The presented model is based on the network reification principle and consists of several reification levels. Two supplementary models are also presented that explore the effects of epigenetic and standard therapy. It turns out that the designed fifth-order network models are fit to model the role of epigenetic modification in BPD and the efficacy of some therapies, based on conducted simulation experiments.