This chapter takes up how Husserl responds to the limitations of the earlier formulations of transcendental phenomenological method by going back to the origin of inquiry in individual facticity. More exactly, I show his determination of inquiry as an activity that appears within a striving for determination in the intentional life of the individual. In this, I stress Husserl’s analysis of how the inquiry seeks to determine and to differentiate meaningful being, even beyond that given in perception. I also bring to the fore an important distinction between interest and disinterest, where the latter detaches from practical interests and concerns in order to strive to determine and to differentiate matters in themselves and in relation to each other. This distinction is essential for understanding science and, indeed, phenomenological science, insofar as these disinterestedly inquire into the “things themselves.”