Implant design optimization can maximize the performance of biological structures. Specifically, the thread pitch of implant systems is a key parameter that promotes stability, distributes loading transfer, preserves alveolar bone, and leads to complete osteointegration. Biomechanics in implantology seeks to analyze the stress and strain states within the mandibular bone and the osseointegrated implant. Numerical analyses provide accurate approximate solutions for understanding the structural behavior of components under complex clinical conditions. Hence, the primary objective of this research was to numerically analyze the biomechanical response of optimizing the thread pitch under functional loading conditions, assessing the dissipation of stress and strain fields in the jaw molar region and on the implant itself. The results of this study revealed a 25% and 22% reduction in maximum stress distribution in the gingival and cortical bone structures, respectively, under occlusal and oblique forces. Additionally, peak von Mises stress was minimized by 32% and 36% in cancellous bone. Therefore, this research contributes to understanding how the optimization of thread features can lead to the advancement of more effective overall mechanical performance in implant systems, thereby enhancing osteointegration through a biomechanical criterion and preserving the well-being and quality of life in patients.