In the teaching of fashion and apparel majors at universities, sewing technology training is an indispensable component. However, college students often suffer injuries and strains during the learning process of sewing skills, which are related to multiple factors such as individual students, teaching methods, and laboratory environments. Through a survey of the main injuries and strains that occur during college students’ sewing processes, the vulnerable body parts prone to injury and strain are summarized. Additionally, through in-depth interviews, observational research, professional judgment, and other methods, it is concluded that the primary causes of injuries and strains include inattention, unskilled techniques, incorrect sewing postures, and other factors. This paper proposes teaching improvement methods from three aspects, such as the teaching process, teaching hardware, and emergency support systems.