This study investigates the levels of burnout among healthcare professionals, its impact on job performance, and its relationship with organizational sustainability. The research employs a descriptive and correlational design, utilizing a sample of 101 healthcare workers from various roles and organizations. A structured questionnaire with Likert-scale questions was used to collect data, which was then analyzed using descriptive and inferential statistics, including correlation analysis. The findings reveal moderate levels of burnout across dimensions such as emotional exhaustion, physical fatigue, and motivation. Burnout significantly affects job performance, including quality of patient care, concentration, efficiency, and job satisfaction. Furthermore, burnout is perceived to contribute to organizational challenges, including employee turnover and decreased organizational sustainability. Although there is some recognition of burnout’s impact, respondents indicated that organizational support systems are inadequate in addressing these issues. The study underscores the need for comprehensive burnout prevention strategies, including improved workload management, employee well-being programs, and enhanced support systems to promote both individual and organizational health. Recommendations include enhancing leadership initiatives, fostering work-life balance, and strengthening mental health support within healthcare organizations.