The COVID-19 pandemic’s economic waves prompted healthcare organizations to develop digital systems that now track operations, report patient data, and maintain digital contact. The study investigates how pandemic-related techno-stress affects female staff members in a top medical hospital of India. Digital technology usage caused techno-stress which presented itself as fatigue and cognitive overload as well as anxiety among workers. The research design combines surveys and semi-structured interviews to discover which digitalization speed and inadequate training and technology adaptation pressure under high clinical demands function as the major stress factors. This study investigates the prevalence and impact of techno-stress among women employees in a super specialty hospital in India during the COVID-19 pandemic. New digital systems used in patient care and reporting and remote coordination work created intense stress during this period. A research survey involved 150 female workers in healthcare including medical staff together with nursing personnel and administrative support staff. The study marked that 74% of participants exhibited medium to strong techno-stress symptoms while 68% reported having issues adjusting to new technology systems while experiencing pressure. Lack of training was responsible for worsening their stress levels according to 59% of participants while 63% experienced work-life balance deterioration from increased screen time responsibilities. Emotional exhaustion affected seventy-one percent of respondents and forty-five percent distinctly associated techno-stress factors to their condition.