As economic globalization intensifies and cross-cultural exchanges proliferate, brand visual design in cross-cultural regions confronts critical challenges: the pronounced limitations of conventional methodologies, inadequate expression of multicultural integration, and constrained participation among diverse ethnic communities. This investigation seeks to construct innovative brand visual design methodologies tailored to cross-cultural regional characteristics, utilizing the Guangdong-Hong Kong-Macao Greater Bay Area as an exemplar to explore dynamic brand visual expression strategies within contexts characterized by multicultural diversity and rapid development. The research employs a mixed-method paradigm that synthesizes literature review, case analysis, and in-depth interviews. Through systematic examination of brand design practices in renowned cross-cultural cities and regions, alongside comprehensive assessment of contemporary dynamic brand design paradigms, this study conducts rigorous analysis of exemplary cases to identify innovative characteristics while delineating design constraints. Subsequently, by collecting brand design cases from the Greater Bay Area and conducting in-depth interviews with nine participants representing diverse backgrounds, the research extracts core requirements for brand design within this cross-cultural context. Building upon these findings, the study develops a dynamic brand design methodology framework encompassing “landscape → imagery → data → familiar territorial texture → visual text → brand carriers → co-creation and sharing,” thereby establishing a cross-cultural dynamic brand visual expression system that integrates multicultural landscapes while facilitating evolutionary development. Furthermore, a collaborative brand visual co-creation platform is constructed to facilitate meaningful participation from diverse communities in brand design processes. The research successfully transcends the limitations inherent in traditional cross-cultural regional brand design by establishing an open-ended brand visual design system that synthesizes diverse landscapes with dynamic evolution. This achievement represents a paradigmatic shift from complex contextual approaches toward dynamic integration in brand visual design. Consequently, this methodology provides both a systematic theoretical framework and practical pathway for cross-cultural regional brand visual design.