Lower limb injuries involve many or all components of the limb architecture—namely, osseous, articular, vascular, skin, and soft tissue as well as elements. Rehabilitation after such injuries is highly variable and depends on the nature and severity of extremity injury, associated injuries, and any comorbidities that the patient may have. The goals of therapy should be graduated and tailored to the patient’s individual needs and abilities. Rehabilitation goals include promoting healing, restoring range of motion and strength, controlling edema, alleviating pain, and preventing complications involving skin, bones, joints, muscles, and neurovascular elements. Most patients who undergo lower extremity reconstruction are subsequently immobilized on bed rest. In-bed positioning is crucial for preventing contracture and pressure ulcers and for managing pain. Range of motion exercises, progressing from passive to active activities, should be prescribed. A program for activity both in and out of bed and early mobilization should be commenced as soon as possible, depending on the injury and patient’s stability. Subsequently, the patient should follow a program to encourage mobility according to weight-bearing status.