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Epigenetics and epitranscriptomics represent distinct levels of gene expression regulation that orchestrate phenotypic changes at cellular and systemic levels. The underlying mechanisms and associated molecular machinery are pivotal in cancer progression, particularly within solid tumors such as colorectal cancer (CRC), breast cancer (BC), and neuroblastoma (NB). These regulatory processes are mediated by DNA and RNA modifiers, categorized as writers, readers, and erasers. Key epigenetic modifications include DNA methylation, histone modifications, non-coding RNAs (ncRNAs), and chromatin remodeling. Epitranscriptomics involves the chemical modification of RNA molecules, influencing their stability, splicing, and translation. This chapter explores the effects of dysregulated epigenetic and epitranscriptomic mechanisms in solid tumors, highlighting emerging epigenetic therapeutic targets. The chapter also introduces novel therapeutic strategies focused on targeting RNA-modifying enzymes and discusses relevant ongoing clinical trials. Finally, the chapter examines the crosstalk between epigenetics and epitranscriptomics, considering potential applications in precision oncology and personalized cancer therapies.

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Emerging Regenerative Therapies for Solid Tumors: Epigenetics and Epitranscriptomics Crosstalk

  • 章节

  • 发表日期：

    2026年

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  • Alaa A. Al-Shazly,
  • Asmaa Khairy,
  • Basmala M. Emam,
  • Mohamed R. Kabeel,
  • Rawan A. Mostafa,
  • Radwa Ayman Salah,
  • Mostafa S. Ibrahim,
  • Nagwa El-Badri

摘要

Epigenetics and epitranscriptomics represent distinct levels of gene expression regulation that orchestrate phenotypic changes at cellular and systemic levels. The underlying mechanisms and associated molecular machinery are pivotal in cancer progression, particularly within solid tumors such as colorectal cancer (CRC), breast cancer (BC), and neuroblastoma (NB). These regulatory processes are mediated by DNA and RNA modifiers, categorized as writers, readers, and erasers. Key epigenetic modifications include DNA methylation, histone modifications, non-coding RNAs (ncRNAs), and chromatin remodeling. Epitranscriptomics involves the chemical modification of RNA molecules, influencing their stability, splicing, and translation. This chapter explores the effects of dysregulated epigenetic and epitranscriptomic mechanisms in solid tumors, highlighting emerging epigenetic therapeutic targets. The chapter also introduces novel therapeutic strategies focused on targeting RNA-modifying enzymes and discusses relevant ongoing clinical trials. Finally, the chapter examines the crosstalk between epigenetics and epitranscriptomics, considering potential applications in precision oncology and personalized cancer therapies.