Louisa Hall’s Reproduction (2023) contrasts two different types of pregnancy and mothering: the narrator’s natural pregnancies are opposed to her friend Anna’s, which are scientifically achieved with recourse to gene-editing techniques. Anna’s experimental procedure appears to gravitate toward an ethical slippery slope leading to unregulated eugenics and ‘designer babies,’ evoking Frankenstein’s efforts. Reproduction addresses the question of what is ‘natural’ in reproduction, and of whether, as new reproductive technologies are introduced, there is a moral obligation to genetically select and screen embryos. This is a discussion conducted between Anna and the narrator, with the novel implicitly suggesting that a balance between the two positions would be the desirable outcome, while placing the emphasis on creating a healthier experience for women during pregnancy. These and related thematic concerns are analyzed with recourse to recent work on the bioethics pertaining to polygenic embryo screening and the moral implications of editing embryos.