Cardiac disease and cancer are the two most common medical conditions in the developed world. The rates of death for heart disease and malignant neoplasms remain very high. As we age, they tend to co-exist. Cancer can affect the heart as metastasis or due to the complexity of the heart, cancer can directly emanate from within heart as benign growths or malignant neoplasms. As cancer treatments have become more and more successful over the years, it is important to realize that some of these advances have led to increased cardiovascular morbidity and mortality due to the development of unintended cardiac side-effects. This chapter summarizes chemotherapeutic and radiotherapeutic interventions most commonly associated with cardiovascular disease (CVD), recommendations for surveillance monitoring, possible treatments, and cardiac tumors that the general cardiologist should be aware of during routine consultation and office based care.