Key performance indicators (KPIs) are vital tools for measuring and guiding performance in any organization, and they play a transformative role in healthcare management. This chapter examines how a KPI-driven approach shifts decision-making from intuition to data-based strategies, enabling more effective monitoring of clinical outcomes, patient safety, operational efficiency, and financial health. After defining core KPI categories—clinical quality (e.g., mortality and readmission rates, infection rates), patient safety (medication errors, fall rates), operational efficiency (bed occupancy, length of stay), and patient satisfaction (communication quality, overall experience)—the text illustrates their application within an internal medicine department. Real-world examples show how tracking rising readmissions for heart failure prompted enhanced discharge protocols, or how elevated hospital-acquired infection rates led to stricter antiseptic measures, each driving measurable improvements. The chapter also introduces Daily and Weekly Management practices: brief daily huddles to review key metrics, address immediate issues, and align teams, paired with weekly review meetings for deeper analysis, strategic planning, and cross-departmental coordination. These routines support real-time problem-solving, continuous process refinement, and stronger staff engagement. By embedding KPI monitoring and regular management cycles into everyday workflows, healthcare leaders can identify inefficiencies early, optimize resource use, and sustain continuous quality improvement—ultimately advancing patient outcomes, operational excellence, and organizational agility.