Supratentorial brain tumors, predominantly gliomas and metastatic lesions, encompass a diverse array of intra-axial and extra-axial neoplasms. Despite advancements in radiation therapy and systemic treatments, surgical intervention remains the primary approach for most brain tumors. Intra-axial tumors often infiltrate essential cortical and subcortical regions, while extra-axial tumors can displace eloquent brain areas, presenting significant challenges in achieving maximal tumor resection while preserving neurologic function. In this setting, intraoperative neuro-monitoring (IONM) has emerged as a vital tool in guiding surgical resection and protecting critical neural structures.