Apert syndrome, a rare congenital disorder characterized by craniosynostosis, syndactyly, and midface hypoplasia, exemplifies the systemic challenges faced by individuals with rare diseases across the globe. This chapter explores the intersection of Apert syndrome with global health policy and surgical system strengthening, emphasizing disparities in diagnosis, access to care, and long-term outcomes, particularly in low- and middle-income countries. It examines structural barriers, including workforce shortages, geographic inequities, and financial hardships, while highlighting innovative solutions such as digital health, capacity building, and national surgical, obstetric, and anesthesia planning. The chapter also traces the evolution of global surgery and rare-disease policy within frameworks such as universal health coverage and the United Nations Sustainable Development Goals. Case studies from Brazil, Africa, and Asia illustrate the power of community-driven advocacy, cross-sectoral partnerships, and ethical policymaking. Ultimately, we advocate for the comprehensive integration of rare diseases, such as Apert syndrome, into national health systems and global policy agendas. Grounded in principles of equity, inclusion, and justice, this integration requires sustained political will, innovative financing mechanisms, and collaborative leadership to ensure no patient is left behind.