Orthognathic surgery plays a key role in the treatment of patients with Apert syndrome, especially in correcting skeletal deformities across the three spatial planes when methods such as osteogenic distraction are insufficient. This surgery is essential for addressing the characteristic mandibular alterations in these patients, who often require correction after procedures like Le Fort III osteotomy. The goal of orthognathic surgery has evolved over time, expanding its focus on functional occlusion correction to also include addressing facial aesthetics, airway expansion, and functional balance. In the case of Apert syndrome, it is well established that surgical approaches such as osteogenic distraction during childhood and orthognathic surgery in adulthood can correct occlusion, facial volume, and airway issues. In the rehabilitation process, osteogenic distraction is typically used in the early stages to correct skeletal abnormalities in the mid and upper thirds of the face. However, this procedure may not resolve occlusion issues, thus necessitating orthognathic surgery in later stages for complete skeletal correction, particularly for the maxilla and mandible. This approach is more predictable than distraction methods and provides three-dimensional correction of occlusion, which is crucial for achieving stable outcomes. Apert syndrome is characterized by skeletal and dental anomalies, such as maxillary hypoplasia, anterior open bite, dental crowding, and dental agenesis. These features complicate orthodontic treatment, requiring specific preparations, such as arch expansion and careful management of dental extractions.