While existing literature has highlighted the influence of female leadership on business strategies, sustainability and adoption of ethical practices, with reference to the specific Made in Italy sector to date there has been no analysis in this regard. In this context, this study through the selection of a successful case study aims to investigate whether the adoption of women’s empowerment programs and tools can foster greater attention to gender issues in the Made in Italy sector. To achieve the research objective, authors employed a case study that enables the investigation of events within their context (Blaikie, 2000) and the acquisition of a comprehensive description of a phenomenon (Yin, 2018). In particular, the positive correlation between the Made in Italy sector and the female empowerment was analyzed through the experience of Gucci, the Italian luxury fashion house, that: (i) implemented internal policies that allowed it to improve female diversity and inclusion; (ii) in 2013 launched Gucci Chime, a global campaign for gender equality. In the context of studies that have analyzed sustainability and the link between sustainability and fashion industries, this study, as far as the authors are aware, is the first to verify whether the Made in Italy could be a sector in which to develop female empowerment’s best practices. This analysis was carried out in response to requests from the literature, which highlighted the need to pay more attention to disclosure on gender equality issues, gender inclusion policies and women’s empowerment initiatives. Authors believe that the results of this study can provide companies operating in the Made in Italy sector, and beyond, with insights to encourage the adoption of women’s empowerment programs and initiatives that can reduce the gender gap and improve corporate brand reputation.