The aim of this research is to describe the role of women in the innovation of Made in Italy fashion industry. The research methodology applied to this paper is the qualitative method through the application of the case study analysis. We selected a privatal case study. Sources of analysis were firm information and data analysis and a questionnaire that was drawn up to be submitted. The research delves not simply into the theme of made in Italy, but in the innovation of made in Italy in a specific industry, that of fashion and it deepens the impact of female entrepreneurial choices in promoting this innovation. This represents a novelty compared to the traditional reference literature. The paper enriches the existing literature through study and results that are a useful baseline for academic and practitioners’ implications about the evolution of the research in the role that women play in leading Italian fashion innovation processes.