Wound healing is a complex cascade of interactions among different cells, growth factors, and extracellular matrix components, and currently some of its aspects are still not fully understood. While the physiopathology of wound healing outlines the main phases of tissue regeneration, it also highlights the influence of many internal and external variables on cellular and tissue microenvironments. The body’s protective mechanisms are most beneficial when they occur during the process of wound healing. The wound healing process is made up of four important phases, including hemostasis, inflammation, proliferation, and remodeling, which eventually repair or regenerate the injured tissue. Although the wounds are created in different organs and tissues, cutaneous wound healing is introduced as a fundamental framework for describing the wound-healing process. Nonetheless, several types of wounds exist within the cutaneous tissue, which create distinctions in this fundamental framework. In this chapter, we want to review the physiopathology of wound healing and the factors that influence this process. Furthermore, our attention will be directed toward the pathophysiology of specific skin wound types.