The process of wound repair represents a challenge for clinical practitioners and researchers, as it represents the intrinsic capacity of the body to recover from injury. Skin tissue healing is divided into four distinct phases: hemostasis, inflammation, proliferation and remodeling. The transition between these phases is dependent on cell-to-cell interactions, which are mediated by both cytokines and chemokines. The healing process may be impaired by several factors, including wound size, infection, decreased vascularization or systemic illnesses. The conventional approach to the prompt healing of skin wounds employs the use of natural products, also called wound dressings, that possess anti-inflammatory, antioxidant and antimicrobial properties. In recent years, the field of regenerative medicine has become an outstanding area of research, aiming to develop artificial tissues and organ regeneration techniques to address significant challenges in human health. The combination of biocompatible scaffolds or structures that resemble the natural extracellular matrix together with stem cells, platelet derivatives, vascular stromal fraction and multiple biological factors has attracted extensive attention in the field of wound regenerative medicine. Indeed, scaffolds facilitate the delivery and application of stem cells for the purposes of tissue regeneration, as well as the upregulation of specific molecular signaling pathways that are pivotal for the repair of the skin.