Premature ejaculation (PE) is a common male sexual problem and has been called early ejaculation or rapid ejaculation. Patients with PE are characterized as having quick ejaculation latency time, lacking control over ejaculation, and suffering from negative personal consequences. Also, PE is a condition with biological factors, not just psychosexual, given our understanding of the underlying neurobiology. Furthermore, a single treatment modality is often ineffective. At present, the ideal PE therapy remains elusive since contemporary non-surgical treatments do not guarantee complete clinical efficacy and only provide a temporary delay in the ejaculation latency time, with PE recurring when the treatment is stopped. As the causative factors in PE are multifactorial, a holistic patient management plan composed of pharmacological management, psychological support, and psychosexual behavioral therapy is likely to produce the best outcomes for patients, and perhaps surgical intervention(s) may have a role in the carefully selected patients. The following chapter provides a narrative review of the different PE definitions, neurobiology, clinical assessment, and treatment options, including psychosexual, pharmacological, surgical, and combined treatments. The emphasis is placed on providing a holistic and multidisciplinary approach with the incorporation of various treatment strategies, including a better understanding of the neurophysiology and psychosocial impacts of PE on the man and his partner.