Nutrigenomics, an interdisciplinary field integrating nutrition, genetics and molecular biology explores relationship between the human genome and dietary components. This science applies novel ‘omics’ technologies that include proteomics, transcriptomics and metabolomics in order to understand how nutrients influence gene expression and metabolic pathways at a molecular level, ultimately impacting disease and health vulnerability. By personalizing the food and nutrient intake according to individual person’s own genetic composition. Nutrigenomics aims to go beyond generic dietary recommendations towards personalized nutrition. This individualized strategy has enormous potential for avoiding chronic diseases, managing existing conditions and improving health effects. The establishment of nutraceuticals and future-oriented functional foods with targeted health benefits based on individual genetic profiles is a significant use of nutrigenomics. However, translating nutrigenomic insights into effective food products and dietary guidelines faces numerous challenges, including the complexity of nutrient-gene interactions, the need for robust scientific evidence from large-scale studies, integrating vast ‘omics’ datasets, addressing ethical and regulatory issues, ensuring food safety, understanding consumer perception and developing adequate training for health professionals. Despite these hurdles, the future of nutrigenomics in informing food product development and revolutionizing nutrition-based care appears promising paving the way for genotype-dependent foods that enhance well-being and disease management.