This chapter outlines key principles for managing chronic diseases among adolescents in the Middle East, emphasizing realistic expectations, sustained primary care relationships, family engagement, and sensitivity to cost and resource limitations. Physicians are encouraged to integrate preventive counseling, basic physical therapy skills, and psychosocial support while also facilitating patient self-management and peer connection. The Middle Eastern perspective highlights strong family structures, variable health literacy, and faith-based outlooks that shape care expectations. In some countries, limited access to multidisciplinary teams and first-line therapies necessitates adaptable approaches. Conditions addressed include type 1 diabetes, inflammatory bowel disease, asthma, acne, epilepsy, and cerebral palsy, with a focus on achievable treatment goals and locally feasible interventions. The authors advocate for culturally sensitive, family-centered, and resource-aware care models that enable adolescents to transition effectively into adulthood while managing their chronic illnesses.