The combination of the development of new materials for the structural upgrade of historical architectural heritage and full-scale experimentation is one of the keys to technological progress and the transfer from scientific research to engineering practice. In the field of seismic protection of architectural heritage, the possibility of reproducing full-scale constructions in the laboratory and subjecting them to shaking table simulations is an exceptional opportunity for research. This chapter presents two experimental campaigns aimed at evaluating the contribution of new systems for the seismic reinforcement of historic masonry buildings. The technologies under experimentation are: (i) reinforced plaster with fiberglass mesh (Composite Reinforced Mortar, CRM) applied to the outer face of masonry only; (ii) restoration of the transversal connection of fair-face stone walls using carbon fibre connectors; and (iii) seismic upgrade by a combined intervention of reinforced plaster with fiberglass mesh on the inside and repointing of the mortar joints of the outer face with stainless steel cords. The research took advantage of the cooperation with some Italian companies recognized among the most active in the field of technologies for cultural heritage and of the participation of the ENEA Casaccia Research Centre where the seismic simulations were carried out. The research had the financial support of the extended Changes partnership, spoke 7, as well as the contribution of research projects funded by the Lazio Region and the Civil Protection, but above all it was possible thanks to the passionate participation of the Structures research group of the Department of Civil, Computer and Aeronautical Engineering of Roma Tre University.