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A novel series of 3′-(2-(substituted-phenyl)-2-methyl-4-oxothiazolidine-3-carbonyl)-6- substituted-spiro[indoline-2,2′-thiazolidine]-3,4′-dione and 3′-(2-(substituted-phenyl)-2-methyl-4-oxothiazolidine-3-carbonothioyl)-6- substituted-spiro [indoline-2,2′-thiazolidine]-3,4′-dione derivatives were synthesized with good to excellent yield. The precursor imine has been formed by reaction of acetophenone with urea and thiourea then reacting the resulting products with thioglycolic acid to yields thiazolidine-Carboxamide and thiazolidine-carbothioamide which again formed imine by reaction with isatin to afford final spiro derivatives, further cyclization take place by the reaction of thioglycolic acid. The structures of the synthesized spiro derivatives were elucidated by their compatible spectral data given by U-Visible, Infra-Red-KBr, Proton Nuclear Magnetic Resonance and Mass. The prepared compounds depicted good antimicrobial activities with MIC ranged from 100 and 6.25 μg/mL. Among the synthesized compounds, 8b exhibited promising antimicrobial activity against A. clavatus MTCC1323 and Staphylococcus pyogenes MTCC 442 with MIC value of 6.25 μg/mL for both these stains.

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Designing, Synthesis and Characterization of Novel Heterocyclic Derivatives of-oxothiazolidine-3-carbonyl)-6- substituted-spiro[indoline-2,2′-thiazolidine]-3,4′-dione and -oxothiazolidine-3-carbonothioyl)-6- substituted-spiro [indoline-2,2′-thiazolidine]-3,4′-dione and their Bioevaluation

  • 会议论文

  • 发表日期：

    2026年

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  • Ayushi Sahu,
  • Shreya Dwivedi,
  • Anoop K. Awasthi,
  • Nitin Srivastava,
  • Krishna Srivastava

摘要

A novel series of 3′-(2-(substituted-phenyl)-2-methyl-4-oxothiazolidine-3-carbonyl)-6- substituted-spiro[indoline-2,2′-thiazolidine]-3,4′-dione and 3′-(2-(substituted-phenyl)-2-methyl-4-oxothiazolidine-3-carbonothioyl)-6- substituted-spiro [indoline-2,2′-thiazolidine]-3,4′-dione derivatives were synthesized with good to excellent yield. The precursor imine has been formed by reaction of acetophenone with urea and thiourea then reacting the resulting products with thioglycolic acid to yields thiazolidine-Carboxamide and thiazolidine-carbothioamide which again formed imine by reaction with isatin to afford final spiro derivatives, further cyclization take place by the reaction of thioglycolic acid. The structures of the synthesized spiro derivatives were elucidated by their compatible spectral data given by U-Visible, Infra-Red-KBr, Proton Nuclear Magnetic Resonance and Mass. The prepared compounds depicted good antimicrobial activities with MIC ranged from 100 and 6.25 μg/mL. Among the synthesized compounds, 8b exhibited promising antimicrobial activity against A. clavatus MTCC1323 and Staphylococcus pyogenes MTCC 442 with MIC value of 6.25 μg/mL for both these stains.