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Nature and natural components have been in use from time immemorial for healing several ailments of humankind. Presently, pertaining to the side effects incurred by the use of chemicals in synthetic drug materials, people are more inclined towards the usage of natural Phyto-compounds as therapeutic agents against myriads of diseases. In the present study, two important Phyto-compounds, Chlorophyllin (CHL) and Curcumin (CUR), which are our culinary companion and are easily available and affordable, have been used to investigate their efficacy against food additive induced hyperglycemia and its associated complications. The results revealed that both the Phyto-compounds were effective in inhibiting ROS generation in the pancreas and liver and could restrict hyperglycemia induced damage in the morphology of both tissues. Additionally, the architecture of brain and testes were also restored by these phyto-compounds even after the initiation of hyperglycemia in the experimental model. CHL and CUR also effectively inhibited the frequency of formation of comet tailed pancreatic cells when pre-treated prior to hyperglycemic induction. Although both the drugs showed similar results however, the results obtained from the comparative assessment for both the Phyto-compounds showed better results for CHL treatment than that of CUR treated group in terms of inhibition of blood glucose level, ROS generation and other parameters related to hyperglycaemia. Therefore, this study definitely suggests the possibility of using these two Phyto-compounds in the daily diet which would definitely help diabetic patients to survive better with a longer life.

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Evaluation of Preventive Efficacy of Different Phytocompounds to Combat Hyperglycemia in Mice Model: A Comparative Assessment

  • 会议论文

  • 发表日期：

    2026年

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  • Sayoni Dam,
  • Sujan Murmu,
  • Amar Faruk Saheb,
  • Tamanna Khatun,
  • Barsha Roy,
  • Astha Saha,
  • Debapriya Ghosh,
  • Ashaporna Biswas,
  • Banani Bhattacharjee,
  • Arnob Chakrovorty,
  • Sisir Nandi,
  • Asmita Samadder

摘要

Nature and natural components have been in use from time immemorial for healing several ailments of humankind. Presently, pertaining to the side effects incurred by the use of chemicals in synthetic drug materials, people are more inclined towards the usage of natural Phyto-compounds as therapeutic agents against myriads of diseases. In the present study, two important Phyto-compounds, Chlorophyllin (CHL) and Curcumin (CUR), which are our culinary companion and are easily available and affordable, have been used to investigate their efficacy against food additive induced hyperglycemia and its associated complications. The results revealed that both the Phyto-compounds were effective in inhibiting ROS generation in the pancreas and liver and could restrict hyperglycemia induced damage in the morphology of both tissues. Additionally, the architecture of brain and testes were also restored by these phyto-compounds even after the initiation of hyperglycemia in the experimental model. CHL and CUR also effectively inhibited the frequency of formation of comet tailed pancreatic cells when pre-treated prior to hyperglycemic induction. Although both the drugs showed similar results however, the results obtained from the comparative assessment for both the Phyto-compounds showed better results for CHL treatment than that of CUR treated group in terms of inhibition of blood glucose level, ROS generation and other parameters related to hyperglycaemia. Therefore, this study definitely suggests the possibility of using these two Phyto-compounds in the daily diet which would definitely help diabetic patients to survive better with a longer life.