Sustainable development demands cleaner greener synthesis in the pharmaceutical sector. Cleaner, greener synthesis may be done with the help of ionic liquids which are versatile class of green solvents which have several advantages over traditional medium. Ionic liquids are “designer solvents” whose properties like solubility, density, refractive index, and viscosity can be ameliorated to fit better as per requirements. This is done by structural modification of its anionic or cationic part or both. Ionic liquids have been extensively employed for the several synthetic transformations desired in medicinal chemistry. Heterocycles, which possess a key role in medicinal chemistry, have been synthesized using a variety of structurally diverse ionic liquids. Among these heterocycles quinoline plays a prominent role in drug discovery research and its cleaner greener and efficient synthesis has to be explored via ionic liquids. In this review, I will discuss the recent advances in the synthesis of various kinds of quinolines using a variety of ionic liquids