Within the past few decades, tick-borne diseases (TBDs) have gained increased recognition as an important problem for both human and veterinary medicine. The global increase in average temperature is likely to expand the range and the number of living ticks as well as increase the total number of TBDs. This chapter investigates how climate change affects TBDs ecology and explains how climate change initiates new diseases, what ecological and environmental factors influence disease risk, and where the gaps in surveillance and health systems are. Moreover, it addresses emerging adoption and mitigation of preventive measures such as integrated vector control, climate-smart public health policies, and new directions in the development of vaccines. One Health approach is important in the climate change human health system which is one response in countering the worst effects and disease in the modern world.