Global environmental conditions are changing due to climate change, which has major consequences for vector-borne disease epidemiology. Among these, tick-borne protozoal diseases which are spread by tick vectors, are becoming a major public and veterinary health problem. The effects of climate change on tick prevalence, distribution, and transmission dynamics as well as tick-borne protozoal infection including theileriosis and babesiosis are explored in this chapter. Tick populations and their capacity to spread protozoal infections are impacted by changing habitats, changing precipitation patterns, and rising temperatures. Diseases that were previously limited to temperate regions now have a wider geographic range as a result of tick habitat expansion brought about by warmer climates. Longer transmission seasons may result from modifications to seasonal trends that impact tick life cycles and the protozoa they carry. This information sheds light on possible hazards to animals and people, emphasizing the necessity of proactive monitoring and flexible approaches in the fields of public health and veterinary field. To identify changes in ticks and tickborne disease occurrence, with reference to climate change attribution, and to establish predictive models of animal and public health concerns to prepare for tickborne disease emergence, more integrated One Health surveillance and modeling investigations are required.