The research focuses on developing a cross-sectoral approach to advancing digital economy infrastructure based on smart transport systems in Central Asia. For this purpose, the author conducted an econometric analysis of sectoral economic statistics in Central Asian countries for 2025. The proposed new approach includes, first, a model for stimulating the economic sectors of Central Asia through the development of smart transport infrastructure. Second, this approach includes a promising combination of digital economy infrastructure characteristics, the attainment of which is expected to lead to a systemic increase in economic activity and performance across all major sectors—industry, energy, agriculture, and services. Third, the author presents a set of practical recommendations to develop smart transport systems in each Central Asian country to realize this vision. Fourth, the author describes a rationale for the anticipated benefits that Central Asian countries may gain from optimizing smart transport infrastructure within the context of their digital economies. The research concludes that the greatest potential for boosting economic activity through optimizing smart transport infrastructure lies in the energy and agricultural sectors of the Central Asian digital economy. The benefits of such optimization are found to be most significant in Mongolia, Tajikistan, and India.