3-Monochloropropane-1,2-Diol (3-MCPD) is a contaminant found in processed palm oil. It is formed during the processing of palm oil and is known to have non-genotoxic carcinogenic properties, which means it can cause cancer if consumed in high doses and over a long period. Due to the health risks associated with this contaminant, the European Commission set a maximum limit of 2500 µg/kg (ppb) for 3-MCPD in palm oil as a requirement for the acceptance of the product in 2021. With the new regulation in place, it is required to have a 3-MCPD testing system and demonstrate that their products are safe for distribu-tion to Europe. As a result, a new laboratory specifically dedicated to testing the 3-MCPD parameter using Gas Chromatography Mass Spec-trometry Quadrupole (GCMSMS) instruments is needed. Before designing the laboratory, the research conducted a Hazard Identification, Risk Assessment, and Determining Control (HIRADC) process to identify and control the risks associated with 3-MCPD testing. The risk identification involved observing the laboratory workflow, analyzing the materials used in sample preparation, and assessing the sample preparation processes conducted by senior analysts in the company. The results of the risk identification showed the risk of 20% as high, 10% as medium, and 70% as low. Each risk was evaluated, and control measures were determined accordingly. The evaluation results were then used as a basis for determining the layout and safety measures of the 3-MCPD laboratory, following the reference standards and regulations for laboratories of the crude palm oil industry in Indonesia.