In recent years, the global water demand has surged at twice the rate of the world’s population growth. It has been predicted that demand for water around the globe will surge by 55% from 2000 to 2050. Although access to potable water is considered a fundamental right, many people around the globe are faced with its scarcity. Although the developed world has improved drinking water access, social and spatial disparities still exist. Even though 99% of Americans have access to safe drinking water, the United States faces income and racial disparities in access to water. Despite numerous studies on access to water, there is still a need to investigate and solve disparate access to water. Social determinants of health affecting water disparities include racism, physical location, ethnicity, and socio-economic status. This chapter aims to: (a) describe the impacts of water injustice on health in the United States; (b) identify spatial, racial, and socio-economic disparities in access to water in the United States; (c) highlight efforts made to address water insecurities and disparities; and (d) discuss recommendations to address disparities in access to water. Case studies on the water crises in the Colonias, Navajo Nation, Flint, Michigan, and Wake County reveal how vulnerable communities disproportionately bearing the greater burden of water injustices. Our recommendations include investment in water infrastructure, mandatory testing of private wells, public education, intensification of research on water resource management and equitable allocation of water resources.