The holistic perspective on human beings has a long tradition in medicine. Mind and body are seen as one entity and subsequently cannot be treated separately. Four concepts of traditional medicine with a holistic perspective (originated from China, India, African countries, and Iran) are presented: traditional Chinese medicine, Ayurvedic medicine, Persian-Islamic medicine, and religious and spiritual healing. The joint declaration on primary health care made in 1978 by the WHO and UNICEF led to international recognition of the important role of indigenous practitioners. Accordingly, any folk healing practice that proves to be helpful to the client and useful to the community deserves the support and encouragement of clinicians. The collaboration of indigenous healers and modern clinicians should be encouraged to provide a maximal quality of mental health services for the community. Every physician should be “culturally responsible and humble” when dealing with a patient with emotional problems from a different cultural background.