This chapter examines the evolution and current status of Psychosomatic Medicine (PSM) in Israel, established locally in the 1930s. It begins with illustrative case studies that highlight characteristic psychosomatic phenomena experienced by diverse patient populations within the Israeli context, emphasizing the influence of immigration, cultural diversity, and trauma from ongoing geopolitical conflicts. The historical development of psychosomatic medicine, including the establishment of the Israeli Association for Psychosomatics, the integration of Medical Psychology with Medicine, and the incorporation of psychosomatic principles into medical education, particularly within Family Medicine and Psychiatry, is explored. The chapter further discusses the challenges faced in the realm of PSM, such as gaps in formal training for primary care practitioners and the pressing need for research on the prevalence of psychosomatic symptoms in the healthcare system. The chapter outlines innovative treatment approaches, including hypnosis, mindfulness-based therapies, and psychological interventions, aimed at addressing the complex interplay between mental and physical health in Israel’s unique sociocultural landscape. Ultimately, the chapter presents a vision for the future of PSM in Israel, advocating for enhanced educational initiatives and research support.