Agriculture is being adversely affected by climate change worldwide. This study examined the multiple adoption of Sustainable Climate-Smart Technology (SCST) among farming households in Ondo State, Southwest, Nigeria through a gender lens. A multi-stage sampling procedure was employed in the selection of 232 respondents for the study, while a well-structured questionnaire was set to collect primary data. The respondents were classified into Male-Headed Households (MHHs), de jure Female-Headed Households (FHHs) and de facto FHHs. The analytical techniques used in the study included descriptive statistics, the Z-test, and Multivariate Probit (MVP) regression. The results of the study showed that adoption of irrigation, agroforestry and zero/minimum tillage was low among the respondents. There were significant gender differences in the adoption of zero/minimum tillage, green manuring, improved varieties, integrated pest management, agroforestry, organic farming, and crop rotation. The Z-test result showed that the adoption index of MHHs was not significantly different from that of their female counterparts. The MVP estimates revealed the existence of heterogeneity in the effect of the explanatory variables in the adoption equations. Complementarity and substitutability relationships were observed among the technologies. The study suggests that knowledge and capabilities that promote the broader adoption of sustainable climate-smart technologies should be provided to farming households.