Burnout among healthcare professionals has emerged as a global issue, exacerbated by overwhelming workloads, staffing deficiencies, and inadequate institutional support. The research investigates the frequency of physician burnout in Oman and its potential solution through the application of Artificial Intelligence to streamline clinical workflow. Grounded in literature worldwide and at the regional level, the study highlights burnout’s physical, emotional, and professional impacts, especially for physicians. Although AI has demonstrated efficacy in alleviating administrative loads and enhancing efficiency in several health systems, Oman has not yet effectively integrated these technologies. Using a quantitative cross-sectional design, the study surveyed 52 physicians from various specialties. Findings revealed low-to-moderate burnout levels (M = 2.25) and limited familiarity with AI tools (M = 2.17), alongside very low clinical usage (M = 1.56). Participants expressed weak belief in AI’s ability to reduce burnout (M = 1.88) and showed low support for further AI investment (M = 1.29). A weak but positive correlation was observed between perceived AI efficiency and burnout reduction (r = .252, p = .072), indicating a modest potential benefit. Despite the limited current impact, the study underscores the need for structured AI training, policy frameworks, and improved digital infrastructure. Recommendations include integrating AI into medical education, piloting AI tools in high-burden areas, and expanding research to broader, more diverse populations. The findings highlight AI’s future potential as a strategic solution to support physician well-being and sustainability in Oman’s healthcare system.