Traditional systems of medicine have long used natural products as dietary supplements for health promotion and for the treatment of myriads of diseases. Several societies like India, China, Japan, and Egypt extensively utilize the herbal medicines in their traditional medicinal systems. Ayurveda, India’s age-old traditional system of medicine defines health as body’s equilibrium of physical and mental wellbeing. Herbs popularly known as Rasayanas are used in Ayurvedic practices for rejuvenation and treatment of many neurological and physical ailments. Tinospora cordifolia is one such popular Rasayana herbs of Ayurveda, commonly known as ‘Giloy or Guduchi’. The health promoting effects of Tinospora cordifolia are mainly attributed to its traditional claims of therapeutic activity for the treatment of fever, diabetes, anxiety, obesity, immunodeficiency, memory deficit and cognitive impairments. The aim of this chapter is to review and discuss the scientifically validated health benefits of Tinospora cordifolia as rejuvenating and therapeutic candidate in view of various pre-clinical and clinical reports from literature. Further, this chapter also aims to present the summarized information about different extracts/decoctions and active phytoconstituents of this medicinal plant which are used in traditional medicine system to treat various ailments as well as for their health promoting potential.